Wilkes-Barre is a city in Pennsylvania, which functions as both the administrative hub and the primary population center of Luzerne County. Located along the Susquehanna River in Northeastern Pennsylvania, it had an estimated population of 44,523 in 2025. It is part of the Wyoming Valley metropolitan area, which includes five cities and more than 40 boroughs forming a contiguous urban corridor with an estimated 574,000 residents.