Yreka is a city in and the county seat of Siskiyou County, California, United States, near the Shasta River and about 22 miles south of the state border with Oregon. The city has an area of about 10 square miles (26 km2), most of it land. As of the 2020 census, its population was 7,807, reflecting an increase from 7,765 in the 2010 census. Yreka is home to the College of the Siskiyous, Klamath National Forest Interpretive Museum, and the Siskiyou County Museum.